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Most patients (82%) have required some degree of supplemental oxygen during hospital admission. Maximal degree of respiratory help has included high-flow nasal cannula assist (47%), non-invasive positive pressure ventilation (30%), and invasive mechanical air flow (22%) [63, 70, 72]. Severe circumstances of EVALI have required veno-venous extracorporeal membrane oxygenation (VV-ECMO) with one case continuing to lung transplantation [56, seventy one, 74].
